The presence of SARS-CoV-2 in multiple clinical specimens of a fatal case of COVID-19: a case reportCase Reports Published on 2022-12-222023-07-11 Journal: Journal of Medical Case Reports [Category] COVID19(2023년), [키워드] COVID-19 lymphoma PBMC SARS-CoV-2 severe disease viremia. [DOI] 10.1186/s13256-022-03706-y PMC 바로가기 [Article Type] Case Reports
Impaired immune response drives age-dependent severity of COVID-19Article Published on 2022-12-052022-11-15 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] Adaptive immune response Aggravated Antiviral benefit caused characterized combinatorial treatment correlation COVID-19 disease disease severity function IFN IFN-γ IFN-λ immune response Immunity Immunotherapy Impaired increasing age individual interferon mice reversed SARS-COV-2 infection severe COVID-19 severe disease severity of COVID-19 susceptibility Therapeutic treatment type I virus replication [DOI] 10.1084/jem.20220621 PMC 바로가기
Effectiveness of COVID-19 vaccines against SARS-CoV-2 variants of concern in real-world: a literature review and meta-analysisArticle Published on 2022-12-012022-11-16 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI Analysis Beta booster vaccination caused Clinical outcome collected Coverage COVID-19 vaccine COVID-19 vaccine effectiveness declined Delta driven by Effectiveness eligibility criteria evaluated Evolution Gamma Hospitalization Infection literature review Meta-analysis meta-regression moderate omicron protective vaccine provided public health public health measures Real-world study SARS-CoV-2 SARS-CoV-2 variant searched severe disease supported vaccination Vaccine variant variants of concern variants of concern. virus VoC VOCs [DOI] 10.1080/22221751.2022.2122582 PMC 바로가기
Could red cell distribution width be used for predicting cardiac injury in neonates with COVID-19?Article Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 바이오마커, [키워드] Affect all age group calculated coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 pandemic COVID-19 cut-off value determine Diagnosis died Diseases distribution Fever group Hospitalization illness immature immunologically Inflammation Inflammatory Injury Laboratory life-threatening management nasopharyngeal swab sample Neonatal Neonate Neonates Newborn Patient PCR PCR-positive polymerase chain populations positive Prognosis prognostic prognostic biomarker Prognostic value Red cell Red cell distribution width SARS-CoV-2 SARS-COV-2 infection screened Sensitivity and specificity severe disease significantly higher syndrome systemic inflammatory the patient troponin level troponin levels troponin. were used [DOI] 10.1002/jmv.28050 PMC 바로가기
Association of iron-related biomarkers with severity and mortality in COVID-19 patientsArticle Published on 2022-12-012022-11-15 Journal: Journal of trace elements in medicine and biology [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, [키워드] Activation Analysis analyzed association AUC biological processes Biomarker can be used characterized Combination continuous monitoring contribute Control controls Course COVID COVID 19 COVID-19 COVID-19 patient cutoff point Deceased decrease deficiency demonstrated discharged ferritin healthy individual highest IL-6 immune responses immune system immunomodulatory individual infected with COVID-19 Infection Inflammation iron marker material Mild moderate Mortality multiple regression model outcome oxidative stress parameter patients with COVID-19 receiver operating characteristic recruited regulate required ROC ROC Curve SARS-CoV-2 patients sensitivity serum severe disease severity shown significant difference significantly significantly increased specificity stepwise AIC selection survival susceptibility the cytokine storm the median trace Trace element Trace metals Transferrin Transferrin. variable variety viral infections [DOI] 10.1016/j.jtemb.2022.127075 PMC 바로가기
COVID-19: imbalanced cell-mediated immune response drives to immunopathologyArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome alveolar damage Antiviral caused cell-mediated immune cell-mediated immune response changes in consequence coronavirus coronavirus disease COVID-19 Critical cytokine Cytokine storm effective Endotheliitis exacerbated excessive inflammation fluid overload homeostasis Host host cells immune immune responses immune system Immunological response immunopathology Inflammatory response Invasion involved lung damage Lung injury manifested mechanism NETs neutrophil activation organs pandemic Pathogenesis pathogenesis. pathophysiological progression SARS-CoV-2 SARS-CoV-2-specific immune responses severe disease syndrome therapeutic agent Therapeutic strategies tissue Trigger viral infection [DOI] 10.1080/22221751.2022.2122579 PMC 바로가기
BNT162b2 mRNA COVID-19 vaccine three-dose safety and risk of COVID-19 in patients with myasthenia gravis during the alpha, delta, and omicron wavesArticle Published on 2022-12-012022-11-16 Journal: Journal of Neurology [Category] COVID19(2023년), SARS, 변종, [키워드] Administered Affect Alpha BNT162b2 mRNA BNT162b2 mRNA vaccine contribute COVID-19 COVID-19 mortality COVID-19 vaccine develop disease General population Mild morbidity and mortality Myasthenia myasthenia gravis outcome Patient patients raise reduced risk Respiratory failure risk risk of COVID-19 Safety SARS-CoV-2 SARS-CoV-2 variants severe COVID-19 severe disease significantly higher vaccination Vaccine vaccine dose vaccine. [DOI] 10.1007/s00415-022-11303-8 PMC 바로가기
The impact of an enhanced health surveillance system for COVID-19 management in Serrana, BrazilResearch article Published on 2022-12-012022-10-05 Journal: Public Health in Practice [Category] 진단, [키워드] Brazil Clinical characteristics collected Community conducted cough COVID-19 COVID-19 patients COVID-19 research develop diabetes died disease disease severity epidemiological Evolution Follow-up headache Health Hospitalized hypertension implementation IQR management median age men Mild moderate disease MONITOR myalgia objective participant Patient patients Personal protective equipment positive progression prospective observational cohort public health public health surveillance Research Result SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 positivity SARS-CoV-2 RNA Seven severe disease state study period Support Surveillance Swab Symptom the epidemic variants was increased were assessed women World Health Organization [DOI] 10.1016/j.puhip.2022.100301 [Article Type] Research article
Reduced circulating FABP2 in patients with moderate to severe COVID-19 may indicate enterocyte functional change rather than cell deathArticle Published on 2022-11-052022-11-15 Journal: Scientific Reports [Category] SARS, 바이오마커, 진단, [키워드] acid Alter alteration Biomarker caused cell death change circulating Cohort contribute COVID-19 COVID-19 patient disease dysfunction Europe exclusion FABP2 functional Gut immune include increase in Infection Inflammation Inflammatory responses inhibited marker median metabolites microbial product Mild moderate NMR outliers pathology Patient patients with moderate plasma Plasma marker positive correlation reduced reduction in route of infection SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe disease severe group Severity of disease shown systemic [DOI] 10.1038/s41598-022-23282-x PMC 바로가기
Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics InitiativeArticle Published on 2022-11-032022-11-15 Journal: PLoS Genetics [Category] SARS, 변종, 진단, [키워드] analysis Analysis association chromosome Cohort controls country COVID-19 Deleterious disease expected Genetic genetics Genome-wide association study identify increase in initiative loci outcome outcomes Pathogenesis performed rare variant Result severe disease Support susceptibility the SARS-CoV-2 TLR7 Toll-like receptor variant whole-genome sequencing with COVID-19 [DOI] 10.1371/journal.pgen.1010367 PMC 바로가기